Distinct regulatory mechanisms balance DegP proteolysis to maintain cellular fitness during heat stress
نویسندگان
چکیده
منابع مشابه
Distinct regulatory mechanisms balance DegP proteolysis to maintain cellular fitness during heat stress.
Intracellular proteases combat proteotoxic stress by degrading damaged proteins, but their activity must be carefully controlled to maintain cellular fitness. The activity of Escherichia coli DegP, a highly conserved periplasmic protease, is regulated by substrate-dependent allosteric transformations between inactive and active trimer conformations and by the formation of polyhedral cages that ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2014
ISSN: 0890-9369
DOI: 10.1101/gad.238394.114